International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Investigation the Zinc Oxide Nanoparticle’s Effect on Sex Hormones and Cholesterol in Rat

    , , , ,

Author Affiliations

  • 1 Biology Department, Faculty of Sciences, Payam Noor University of Isfahan, Isfahan, IRAN
  • 2 Biochemistry Department, Faculty of Biological Science. TarbiatModares University, Tehran, IRAN
  • 3 PhysiologyDepartment, Faculty of Sciences, Payam Noor University of Isfahan, Isfahan, IRAN

Int. Res. J. Biological Sci., Volume 2, Issue (8), Pages 54-58, August,10 (2013)

Abstract

Nowadays nanoparticles have widespread application in various industries and medicine because of their special and unique futures. Zinc oxide nanoparticles have increased production and widespread application in biological systems, but there are limited studies in side effects of these nanoparticles. This study done by 48 wistarrats with daily injection of different doses of zinc oxidenano particles intraperitoneally (5, 10, 20 and 40 mg / kg). After a 21 –day period, threats were bled and serum level of LH, FSH and testosterone hormones were measured, blood cholesterol level measured also. The results showed a significant effect of zinc oxide nanoparticles on testosterone and cholesterol level of blood. The results indicate in the dose of 40mg / kg, FSH significantly decreased, but no significant change in LH levels was observed at the doses administered. It’s may be LH and FSH decreased by negative feedback of increased TSH. This study revealed presence of nanoparticle cause decreased FSH and increased TSH and cholesterol and not significant deceased in LH level.

References

  1. Aaseth J., Olsen A., Halse J., Hovig T., Argyria-tissue deposition of silver as selenide, Scand. J.Clin. Lab. Invest.,, 247-251 (1981)
  2. Paull R., Wolfe J., Hébert P. and Sinkula M., Investing in nanotechnology, Nat Biotechnol, 21, 1144-1147 (2003)
  3. Yoshida Y., Itoh N., Saito Y., Hayakawa M. and Niki E., Application of water-soluble radical initiator, 2,2'-azobis [2-(2-imidazolin-2-yl)propane] dihydrochloride, to a study of oxidative stress, Free Radic Res., 38, 375-384 (2004)
  4. Brandt D., Park B., Hoang M. and Jacobe H.T., Argyria secondary to ingestion of homemade silver solution,Am. Acad.Dermatol., 53, 105-107 (2005)
  5. McAuliffe M.E. and Perry M.G., Are nanoparticles potential male reproductive toxicant? A literature review, Nanotoxicol, 204-210 (2007)
  6. Heinlaan M., Ivask A., Blinova I., Dubourguier H.C., Kahru A., Toxicity of nanosized and bulk ZnO, CuO and TiO2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalusplatyurus, Chemosphere, 71, 1308-1316 (2008)
  7. Catherine C.B., Adam S.G., Curtis G.,Functionalisation of magneticnanoparticles for applications in biomedicine, J. Phys. D: Appl. Phys.,36, R198–R2(2003)
  8. Gopinath P., Gogo S.K., Chattopadhay A., Gosh S.S., Implications of silver nanoparticle induced cell apoptosis for invitro gene thrappy, Nanobiotechnology, 19, 075-107 (2007)
  9. Zheng Y., Li R., Wang Y., In Vitro and In Vivo Biocompatibility studies of ZnO Nanoparticles, J Modern Physics,23, 1566-1571 (2009)
  10. Sharma V., Shukla R.K., Saxena N., Parmar D., Das M., Dhawan A., DNA damaging potential of zinc oxide nanoparticles in human epidermal cells, Toxicol Let.,185,211-218 (2009)
  11. Huang Z., Zheng X., Yan D., Yin G., Liao X., Kang Y., Yao Y., Huang D., Toxicological effect of ZnO nanoparticles based on bacteria, Hao. BLangmuir, 24, 4140-4144 (2008)
  12. Serpone N.,Dondi D.,Albini A., Inorganic and organic UV filters: Their role and efficacy in sunscreens and suncare products, Inorg. Chim.,360, 794-802 (2007)
  13. Deng X., Luan Q., Chen W., Wang Y., Wu M., Zhang H., Nanosized zinc oxide particles induce neural stem cell apoptosis, Jiao.ZNanotechnology,20, 115101(2009)