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Evaluation of Iron Oxide nanoparticles effects on tissue and Enzymes of Thyroid in Rats

Author Affiliations

  • 1Department of Biology, Faculty of Sciences, Payam Noor University of Tehran, Tehran, IRAN
  • 2 Biology Department, Faculty of Sciences, Payam Noor University of Isfahan, Isfahan, IRAN
  • 3 Department of Biochemistry, Faculty of Biological Science, TarbiatModares University, Tehran, IRAN
  • 4 Ph.D, Shahid Beheshti University, Tehran, IRAN

Int. Res. J. Biological Sci., Volume 2, Issue (7), Pages 67-69, July,10 (2013)


Objective: Iron oxide nanoparticles have extensive application in MRI and heat therapy of canceras contrast elements. However, the effects of nanoparticles on human health have not been fully investigatedyet. In this study, effects of iron oxide nanoparticles on thyroid hormones (T3 and T4) and TSH in adult male wistar rats were studied. Material and Methods: Three experimental groups of ratswere fed daily by three different concentrations of iron oxide nanoparticles (20 g/kg, 50 g/kg and 150 g/kg that dissolved in one ml of distilled water) by gavage tube. Feeding repeated for 15 days. Then serum T3 and T4 levels was measured in experimental and control groups. Results: Results showed there are no significant changes inserum T4 levels in the experimental group that received lowest dose. But rats received the highest dose showed a significant increase in T3 level compared to control group. Also Yrmy TSH hormone concentration in the groups receiving the middle and max dosage of treatment is significantly lower than the control group. Conclusion: Experimental results also showed high concentration of iron oxide nanoparticles inhibits the Ndkryny pituitary axis and can cause malfunctions of the hypothalamusand thyroid glands.


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