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Anti-Oogenic Evaluation of Seed Extract of abrus Precatorius L. in Swiss Albino Mice

Author Affiliations

  • 1Deptt. of Biotechnology, BNPG College, Udaipur, Rajasthan, INDIA

Int. Res. J. Biological Sci., Volume 2, Issue (6), Pages 27-30, June,10 (2013)


Ethno-botanical reports from Rajasthan reveals utilization of Abrus precatorius L. seeds to check ova formation. So to evaluate its potential ovarian histo-architectural studies were carried out on swiss albino mice treated by body weight dependent seed extract. Ovarian histological observation of test drug treated animals show follicles in different stages of atresia and deviated oestrous cycle revealing its potential as antifertility source. This effect diminishes with time and proceeding restoration of folliculogenesis can be observed after fifteen days of the drug ingestion. Hence the present study embodies Abrus to be prolonged oral fertility regulator.


  1. Katewa S.S. and Arora A., Some plants in folk medicine of Udaipur district (Rajasthan), Ethnobotany,9, 4851 (1997)
  2. Jain A., Katewa S.S., Chaudhary B.L. and Galav P., Folk herbal medicines used in birth control and sexual diseases by tribals of southern Rajasthan, India, Journal of Ethnopharmacology, 90(1), 171-177 (2004)
  3. Arora R., Gill N.S., Kaur S. and Jain A.D., Phytopharmacological evaluation of ethanolic extract of the seeds of Abrus precatorius (L.), Journal of Pharmacology and Toxicology, 6(6), 580-588 (2011)
  4. Bagaria A., Surendranath K., Ramagopal U.A., Ramakumar S. and Karande A.A., Structure-function analysis and insights into the reduced toxicity of Abrus precatorius agglutinin I in relation to abrin, J Biol.Chem., 281, 65-74 (2006)
  5. Agarwal S.S., Ghatak N., Arora R.B. and Bhardwaj M.M., Antifertility activity of the roots of Abrus precatoriusL. Pharmacological Research Communications, 2(2), 159-163 (1970)
  6. Bhatt N.I., Chawla S.L. and Rao M.V., Contraceptive evaluation of seed extracts of Abrus precatorius L. in male mice (Mus Musculus),Journal of Herbal Medicine and Toxicology, 1(1),47-50 (2007)
  7. Zia-Ui-Haque A., Qazi M.H. and Hamdard M.E., Studies on the antifertility properties of active components isolated from the seeds of Abrus precaiorius L. II. Pak J. Zool., 15,141-146 (1983)
  8. Khan Z.F., Saeed M.A. and Ahmed E., Oxytoxic activity and toxic effects of Globulins of Abrus seeds (Scarlet variety) in Rabbits, J of Islamic Academy of Sciences, 6(2),108-113 (1993)
  9. Rugh R., The mouse, its reproduction and development, Burgess, Minneapolis(1968)
  10. Segal S.J. A review of research on physiological control of fertility, J. Reprod. fertil.,2, 533 (1961)
  11. Wischnitzer S., The maturation of the ovum and the growth of the follicle in the mouse ovary, Anat.Rec.,166, 399 (1966)
  12. Hadek R., The structure of the mammalian egg, Int.Rev.Cytol.,18, 29 (1965)
  13. Ingram D.C., The effect of gonadotrophin and estrogens on ovarian atresia in the immature rat, Ist ed., 247-273 Academic Press New York (1959)
  14. Desai V.B. and Sirsi M., The effect of Abrusprecatorius on pregnancy of mice, Curr. Sci,33, 585-587 (1964)
  15. Okoko II, Osinubi A.A., Olabiyi O.O., Kusemijiu T.O., Noronha C.C., Okanlawon A.O., Anti-ovulatory and Anti-implantation potential of the methanolic extract of seeds of Abrus precatorius in the rat, Endocr Pract,11, 554-560 (2010)
  16. Pokharkar R., Saraswat R., Bhavare V., and Kanawade M. GCMS Studies of Abrus Precatorius, Pharmacologyonline 2, 1178-1189 (2011)