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The Assessment of IL-12 P40 among Primary pulmonary and Chronic (Old) Pulmonary Tuberculosis

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Author Affiliations

  • 1College of Sciences, Department of Biology, University of Babylon, IRAQ

Int. Res. J. Biological Sci., Volume 2, Issue (12), Pages 1-4, December,10 (2013)

Abstract

The possible role of Il-12 +P40 assessment as a biomarker for tuberculosis disease is being reported. It was found thatIL-12+p40 can discriminate between PPTB, sputum AFB shedders OPTB and sputum non AFB shedders as concentration means are taken in consideration . Since there were a range of individual variations in tuberculosis patients and controls, reflecting variations in genetic backgrounds of the best control groups. All of the aforementioned forms of tuberculus disease in man rises up the levels of IL-12+P40 . Such IL-12+P40 level rising in OPTB was diseases stage and patients age dependent. Conversely, inhibition occurred in Il-12+P40 levels with chronicity at the age ranges of 25-34y and 40-55y. Sputum AFB shedders in OPTB group associated with high IL-12 +P40 levels, while, the non shedders were with low IL-12+P40 levels . In PPTB group, however, there were with neither age range dependence nor inhibition of IL-12+P40 level could be noted.

References

  1. Al- Damluji S.F., Tuberculosis for Medical Students and Practitioners In Iraq, William – Heinemann Medical Book limited (1979)
  2. Handzel Z.T., Immune response to Mycobacterium tuberculosis infection in humans, In Mahboub , B.H., and Vats M.G. (ed). Tuberculosis , current issues in Diagnosis and Mangment , In Tech (2013)
  3. Kozaiwicz L., Phuah J., Flynn J. and Chan J., The role of B cells and humoral immunity in Mycobacterium tuberculosis infection, Adv. Exp. Biol., 783, 225-250 (2013)
  4. Sallusto F., Leing D., Forster R., Lipp M. and Lanzavecchia A., Two subsets of memory T- lymphocytes with distinct homing potentials and effecter functions, Nature, 401, 708 -712 (2009)
  5. Nemeth J., Winkler H.M., Zwick R.H., Muller C., Rumetshofer, Peripheral T cell cytokine responses for diagnosis of active tuberculosis, Plos one, 7(4), e 53290 (2012)
  6. Tang S., Cui H., Yao L., Hao X., Shen Y., Fan L., Sun H., Zhang Z. and Huang A.J., Increased cytokines response in patients with tuberculosis complicated with chronic obstructive Pulmonary disease, Plos one 8(4), e 6285 (2013)
  7. Suther lend J.S., Adetifa T.M., Hill P.C., Adgebola R.A. and Ota M.O., Patterns and diversity of cytokine production differentiate between Mycobacterium tuberculosis infection and disease, Eur. J. Immunol., 39,723 -729 (2009)
  8. Sutheland J.S., De Jong B.C., Jeffries D.J., Adetifa I.M. and Ota M.O.C., production of TNF alpha , IL-12(P40) and IL-17 can discriminate between active T.B disease and latent infection , in west A fan cohort . Bacterial disease program , medical research council laboratories , Banjul ,the Gambia (2011)
  9. Christine D.F., Clinical Immunology and Serology; A laboratory perspective, Third ed. F.A. Davis Company, Philadelephia, 72-80 (2010)
  10. BioSource, BioSource Europe S.A. Rue de I Industerie, 8-B, 1400 Nivelles, Belgium, Manual leaflet of IL-12 P40 .ELISA, KAP 156 (2010)
  11. Lewis M., Bain J. and Bates I., Deice and Lewis practical Hematology, 10th ed., Churchill Livingstone Elsevier, P 599 (2006)
  12. Grange J.M., Mycobacterium and Human diseases, Edward –Arnold, 119-136 (1988)
  13. Grange J.M. and Zumla A., Tuberculosis, Brit. Med. J., 316, 1962-1964 (1998)
  14. De Jong B.C., Hill P.C., Brooks R.H., Gagneux S., Jefferies D.T. et al., Mycobacterium africanuim elicits an attenuated T-cell response to early secreted antigenic target , 6KDa, in patients with tuberculosis and their household contacts, J. Int. Dis., 193, 1279 -1286 (2006)
  15. Song C.H., Kim H.J., Lim J.H., Kim U.O., Kim J.S., Paik T.H., Kim K.J., Suhr J.W. and J.O. E.K., Depressed interleukin Il-12, but not IL-18 , production in response to 30 or 32 kilodalton mycobacterial antigen in patients with active pulmonary tuberculosis, Infect. Immun.,68(8), 4477-4484 (2000)
  16. Rayan K.J. and Ray C.G., Sherries Medical Microbiology th ed. McGraw hill Medical, New York, 19 -44 (2010)
  17. Brooks G.F., Carrell K.C., Butel J.S., Morese S.A., Mietzner J., Medical Microbiology 25th ed . Lange McGraw – Hill Medical, N.Y., 121-142 (2010)
  18. Paul W., Fundamental of immunology, 6th ed. Walters Kluwer, Lippincott William and Wilkans (2008)