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Potentiality of Vitamin C and / or Lupinus termis to Modulate Blood Glucose level and Oxidative Stress Status of Alloxan-induced Diabetic Rats

Author Affiliations

  • 1Department of Nutrition and Clinical nutrition, Faculty of Veterinary Medicine, Cairo University, Giza 12211, EGYPT

Int. Res. J. Biological Sci., Volume 2, Issue (11), Pages 41-46, November,10 (2013)

Abstract

Lupinus termis (termis) has long been utilized as integral food in developing countries prior to being recognized as a hypoglycemic agent and vitamin C is known as a potent antioxidant. Here we tested the hypothesis that the administration of vitamin C and termis solely or in combination modulates the adverse effects on blood glucose and vitamin C levels, liver and kidney functions as well as oxidative stress biomarkers of diabetes induced by alloxan in Wistar rats. Fifty male Wistar albino rats (110.0± 15.0g) were fed on a standard experimental diet and allotted to five groups; non diabetic control group (C), diabetic control (D) and three diabetic groups each of which were given oral vitamin C (100mg/kg body weight, DVC) or termis (75mg/100g body weight, DT) or their combination at the same levels (DVCT) for four weeks. Induction of diabetes significantly (P0.05) increased the blood glucose and decreased the vitamin C levels as compared to the non diabetic controls, associated with a significant depression in the activity of the kidney and liver function and in the oxidative stress biomarkers. All treatments had positive effects on the measured parameters; however, the combined treatment surpassed the sole treatments in such modulating effects. In conclusion, the combination of vitamin C and termis appears to be a beneficial strategy not only to control hyperglycemia but also to modulate the negative effects of diabetes on kidney and liver function and oxidative stress status.

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