6th International Virtual Congress (IVC-2019) And Workshop.  International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Neem (Azadirachta indica A. Juss) - A Nature's Drugstore: An overview

Author Affiliations

  • 1Department of Preventive and Social Medicine, National Institute of Unani Medicine, Bangalore, INDIA
  • 2Department of Moalajat, National Institute of Unani Medicine, Bangalore, INDIA
  • 3 Department of Ilmul Advia, National Institute of Unani Medicine, Bangalore, INDIA

Int. Res. J. Biological Sci., Volume 1, Issue (6), Pages 76-79, October,10 (2012)

Abstract

In traditional medicine most of the diseases have been treated by administration of plant or plant product. Neem (Azadirachta indica A. Juss) is the most useful traditional medicinal plant in India. Each part of the neem tree has some medicinal property. During the last five decades, apart from the chemistry of the neem compounds, considerable progress has been achieved regarding the biological activity and medicinal applications of neem. It is now considered as a valuable source of unique natural products for development of medicines against various diseases and also for the development of industrial products. This review gives a bird’s eye view mainly on the biological activities of the neem and some of their compounds isolated, pharmacological actions of the neem extracts, clinical studies and plausible medicinal applications of neem along with their safety evaluation.

References

  1. Verkerk R.H.J. and Wright D.J, Biological activity of neem seed kernel extract and synthetic azadirachtin against larvae of Plutella xylostellal, Pesticide science., 37,83-91(1993)
  2. National Research Council Neem: tree for solving global problems, National Academy Press, Washington D.C., (1992)
  3. Schmutterer H., The Neem Tree: Source of Unique Natural Products for Integrated Pest Management, Medicine, Industry and Other Purposes, VCH, Weinheim, Germany, 1–696 (1995)
  4. Girish K. and Shankara B.S., Neem – A Green Treasure. Electronic Journal of Biology., 4(3), 102-111. (20085.Parotta J.A., Healing plants of Peninsular India., New York, CABI Publishing, 495-96 (2001)
  5. Ross I.A., Medicinal plants of the world: Chemical constituents, Traditional and modern medicinal uses, Totowa, New Jersy, 81-85 (2001)
  6. Sharma P., Tomar L., Bachwani M., Bansal V., Review on Neem (Azadirechta indica):Thousand Problem One Solution, Int. Res. J. of Pharmacy2(12), 97-102 (2011)
  7. Djenontin Tindo S., Amusant N., Dangou J., Wotto D.V., Avlessi F., Dahouénon-Ahoussi E., Lozano P., Pioch D. and Sohounhloué K.C.D., Screening of Repellent, Termiticidal and Preventive activities on Wood, of Azadirachta indica and Carapa procera (Meliaceae) seeds oils, ISCA J. Biological Sci.,1(3), 25-29, (2012)
  8. Mondal D. and Mondal T., A Review on efficacy of Azadirachta indica A. Juss based biopesticides: An Indian perspective, Res. J. Recent Sci.,1(3), 94-99 (2012)
  9. Brototi B., and Kaplay R.D., Azadirachta indica (Neem): It’s Economic utility and chances for commercial planned plantation in Nanded District, Int. J. Pharma,1(2), 100-104 (2011)
  10. Ghani N., Khazainul Advia, New Delhi, Idara Kitabul Shifa, 1330-34 (YNM)
  11. Chatterjee A. and Pakrashi S.C., The Treatise on Indian Medicinal Plants, New Delhi: National Institute of Science Communication (CSIR) 75-78 (2010)
  12. Kabeeruddin H., Makhzanul mufradat., New Delhi: Aijaz publishing house 400-11 (2007)
  13. Tandon P. and Sirohi A., Assessment of Larvicidal Properties of aqueous extracts of four plants against Culex Quinquefasciatus Larvae, Jordan Journal of Biological Sciences., 3(1), 1 – 6 (2010)
  14. Aditi G., Bhandari B.S., Rai N., Antimicrobial Activity of Medicinal plants Azadirachta indica A. Juss, Allium cepa . and Aloe vera L., Int. J. PharmTech Res., 3(2), 1059-1065 ( 2011)
  15. Shravan K.D., Ramakrishna R., Santhosh K.M., Kannappan N., In vivo Antidiabetic evaluation of Neem leaf extract in alloxan induced rats, Journal of Applied Pharmaceutical Science.,1(4),100-105 (2011)
  16. Sithisarn P., Supabphol R., Gritsanapan W., Antioxidant activity of Siamese neem tree (VP1209)
  17. J. Ethnopharmacol., 99(1), 109-12 (2005)
  18. Charles V., Charles S.X., The use and efficacy of Azadirachta indica ADR (neem) and Curcuma longa (turmeric) in scabies, A pilot study, Trop. Geogr. Med., 44(1-2), 178-81 (1992)
  19. Mbah A.U., Udeinya I.J., Shu E.N., Chijioke C.P., Nubila T., Udeinya F. et al., Fractionated neem leaf extract is safe and increases CD4+ cell levels in HIV/AIDS patients, Am. J. Ther.,14(4), 369-74 (2007)
  20. Bandyopadhyay U., Biswas K., Sengupta A., Moitra P., Dutta P., Sarkar D. et al., Clinical studies on the effect of Neem Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer, Life. Sci., 75, 2867-2878 (2004)
  21. Isah A.B., Ibrahim Y.K., Iwalewa E.O., Evaluation of the antimalarial properties and standardization of tablets of Azadirachta indica (Meliaceae) in mice, Phytother Res.,17(7), 807-10 (2003)
  22. Manal M.E.T., Siddig I.A.W., Fauziah O., Perichehr H., Ahmad B.A., Adel S.A.Z., In vivo Anti-tumor Effect of Azadirachta indica in Rat liver Cancer, Res. J. Biol. Sci., 4(1), 48-53 (2009)
  23. Talwar G.P., Raghuvanshi P., Misra R., Mukherjee S., Shah S., Plant immunomodulators for termination of unwanted pregnancy and for contraception and reproductive health, Immunol Cell Biol., 75(2), 190-2 (1997)
  24. Joshi S.N., Dutta S., Kumar B.K., Katti U., Kulkarni S., Risbud A., Mehendale S., Expanded safety study of Praneem polyherbal vaginal tablet among HIV-uninfected women in Pune, India: a phase II clinical trial report, 84(5), 343-347 (2008)
  25. Garg S., Doncel G., Chabra S., Upadhyay S.N., Talwar G.P., Synergistic spermicidal activity of Neem seed extract, reetha saponins and quinine hydrochloride, Contraception., 50(2), 185-90 (1994)
  26. Pai M.R., Acharya L.D., Udupa N., Evaluation of antiplaque activity of Azadirachta indica leaf extract gel—a 6-week clinical study, J. Ethnopharmacol.,90(1), 99-103 (2004)
  27. Vanka A., Tandon S., Rao S.R., Udupa N., Ramkumar P., The effect of indigenous neem Azadirachta indica mouth wash on Streptococcus mutans and lactobacilli growth, Indian J. Dent. Res.,12(3), 133-44 (2001)
  28. Obiefuna I., and Young R., Concurrent administration of aqueous Azadirachta indica (Neem) leaf extract with DOCA salt prevents the development of hypertension and accompanying electrocardiogram changes in the rat, Phytother. Res.,19, 792-795 2005
  29. Chattopadhyay R.R., Chattopadhyay R.N., and Maitra S.K., Effects of Neem on hepatic glycogen in rats. Indian J. Pharmacol., 25, 174-175 2000
  30. Ogbuewu I.P., Odoemenam V.U., Obikaonu H.O., Opara M.N., Emenalom O.O., Uchegbu M.C. et al, The Growing Importance of Neem (Azadirachta indica A. Juss) In Agriculture, Industry, Medicine and Envirnment: A Review, Res. J. Med. Plant., 5(3), 230-245 (2011)