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Anti-angiogenic properties of the Jamaican ball moss, (Tillandsia recurvata L.)

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Author Affiliations

  • 1Bio-Tech R and D Institute, Kingston, JAMAICA
  • 2Educational and Scientific Corporation, Florida, USA
  • 3Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA
  • 4Natural Products Institute, University of the West Indies, Mona, JAMAICA

Int. Res. J. Biological Sci., Volume 1, Issue (4), Pages 73-76, August,10 (2012)

Abstract

The island of Jamaica is known for its rich biodiversity and its abundance of medicinal plants being used as ethno medicines. Given the high occurrence of cancer worldwide and the major source of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the anti-angiogenic properties of a chloroform extract from the Jamaican ball moss previously shown to exhibit anti-cancer properties in our lab and its dicinnamate isolates,1,3-di-O-Cinnamoyl-glycerol (D1 ) and (E)-(2-(3-(3-(3,4-dimethoxyphenyl)acryloyloxy)-2-hydroxypropoxy)-2-oxoethyl)triphenylphosphoniumbromide (D2) along with known chemotherapeutic drug, paclitaxel. This was investigated using a modified version of the ex vivo aortic ring sprouting assay. Results show that angiogenesis was reduced in the presence of the chloroform crude extract at 20 µg.ml and 30 µg/ml and also in the presence of D1 at 10 µg/ml and 20 µg/ml when compared to the control. The results substantiate the promising anti-cancer properties of the Jamaican ball moss and may prove useful in anti-cancer agents’ drug discovery.

References

  1. Ministry of Health, Epidemiological profile of selected health conditions and services in Jamaica 1990-2002. Vital statistics report 2002, Registrar General's Dept.(2005)
  2. American Cancer Society, Global cancer facts and figures 2007 Atlanta: American cancer society, Available at http://www.cancer.org/acs/groups/content/
  3. nho/documents/document/globalfactsandfigures2007rev2p.pdf. (2007)
  4. Reinberg S., Cancer killed almost 8 million worldwide in (2007)
  5. World Health Organization, Cancer, Available at http://www.who.int/mediacentre/factsheets/fs297/en/Retrieved on 2007-06-25(2006)
  6. Boyle P. and Levin B., World cancer report, In Available at http://apps.who.int/ bookorders/anglais/ detart1.jsp?sesslan=1&codlan=1&codcol=76&codcch=26Lyon: IARC Press(2008)
  7. Wang S., Zheng Z., Weng Y., Yu Y., Zhang D., Fan W., Dai R., Hu Z., Angiogenesis and anti-angiogenesis activity of chinese medicinal herbal extracts, Life Sciences, 74, 2467-2478 (2004)
  8. Hanahan D., Folkman J., Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis, Cell., 86, 353-364 (1996)
  9. Rosner H., Williams L.A.D., Jung A. and Kraus W., Disassembly of microtubules and inhibition of neurite outgrowth, neuroblastoma cell proliferation and map kinase tyrosine dephosphorylation by dibenzyl trisulphide. Biochimica et Biophysica Acta.,1540, 166-177 (2001)
  10. Williams L.A., Rosner H., Levy H.G., Barton E.N., A critical review of the therapeutic potential of dibenzyl triphide isolated from petiveria alliacea l. (guinea hen weed, anamu), West Indian Med J., 56, 17-21 (2007)
  11. Williams L.A.D., Anti-proliferation/cytotoxic action of dibenzyl trisulphie, a secondary metabolite of petiveria alliacea,Jamaican Journal of Science and technology, 15, 54-60 (2004)
  12. Mitchell S. and Ahmad M., A review of medicinal plant research at the University of the West Indies, jamaica, 1948-2001, West Indies Medical Journal, 55, 243-269 (2006)
  13. Shaziya B. and Goyal P.K., Anthelmintic effect of natural plant (carica papaya) extract against the gastrointestinal nematode, ancylostoma caninum in mice, ISCA Journal of Biological Sciences, , 2-6 (2012)
  14. Jitendra M., Monika S., Dev Ratan S.D., Priyanka G., Priyanka S. and Jayraj Kiran J.D., Micropropagation of an anti-diabetic plant - stevia rebaudiana bertoni, (natural sweetener) in hadoti region of south-east rajasthan, India, ISCA Journal of Biological Sciences, , 37-42 (2012)
  15. Félicien A., Alain A.G., Sébastien A.T., Fidele T.,Boniface1 Y., Chantal M. and Dominique S., Chemical composition and biological activities of the essential oil extracted from the fresh leaves of chromolaena odorata (l. Robinson) growing in benin, ISCA Journal of Biological Sciences, , 7-13 (2012)
  16. Aweng E.R., Hanisah1 N., Mohd Nawi M.A., Nurhanan Murni M., Shamsul M.S., Antioxidant activity and phenolic compounds of vitex trifolia var, simplicifolia associated with anticancer, ISCA Journal of Biological Sciences, , 65-68 (2012)
  17. Hegde C.R., Madhuri M., Nishitha S.T., Arijit D., Sourav B., Rohit K.C., Evaluation of antimicrobial properties, phytochemical contents and antioxidant capacities of leaf extracts of punica granatum l, ISCA Journal of Biological Sciences, , 32-37 (2012)
  18. Shachi S., Antimitotic activity of a new compound isolated from the flower of prosopis juliflora,Research Journal of Recent Sciences, , 22-26 (2012)
  19. Alam E.A., Initiation of pharmaceutical factories depending on more application of biotechnology on some medicinal plants review article (in vitro production of some antioxidant, analgesic, antibacterial, antidiabetic agents), Research Journal of Recent Sciences, , 398-404 (2012)
  20. Gordaliza M., Natural products as leads to anticancer drugs, ClinTransl Oncol, , 767-776 (2007)
  21. Lowe H., Anti-tumour and anti-inflammatory extracts of plant biomass and their uses (2010)
  22. 1.Benzing D., The biology of the bromeliads (1980)
  23. Agra M., Silva K., Basilio I., Freitas P. and Barbosa-Filho J., Survey of medicinal plants used in the region northeast of brazil, Brazilian J. Pharmacognosy, 18(2008)
  24. Grant D.S., Williams T.L., Zahaczewsky M. and Dicker A.P., Comparison of antiangiogenic activities using paclitaxel (taxol) and doxetaxel (taxotere), International Journal of Cancer, 104, 121-129 (2003)
  25. Folkman J., Therapeutic implications, Tumour angiogenesis: New England Journal Medicine, 285, 1182-1186 (1971)
  26. Pasquier E., Carre´ M., Pourroy B., Camoin L., Reba¨ O., Briand C. and Braguer D., Antiangiogenic activity of paclitaxel is associated with its cytostatic effect, mediated by the initiation but not completion of a mitochondrial apoptotic signalling pathway, Molecular Cancer Therapeutics, , 1301-1310 (2004)
  27. Folkman J., Anti-angiogenesis: New concept for therapy of solid tumours, Ann. Surg., 175, 409-416 (1972)
  28. Algire G.H. and Challdey H.W., Vascular reactions of normal and malignant tissues in vivo, I. Vascular reactions of mice to wounds and to normal and neoplastic implants, J. Natl. Cancer Inst., , 73-85 (1945)
  29. Greenblatt M. and Shubik P., Tumor angiogenesis:Transfilter diffusion studies in the hamster by transparent chamber technique, J. Natl. Canc. Inst., 41, 111-124 (1968)
  30. Lau D.H., Xue L., Young L.J., Burke P.A., Cheung A.T., Paclitaxel (taxol): An inhibitor of angiogenesis in a highly vascularized transgenic breast cancer, Cancer Biother Radiopharm,14, 31-36 (1999)